Opioid Agonists
RESTRICTED
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Calculated Induction Dose
--mg
Mechanism of Action
Ultra-short acting opioid ester rapidly hydrolyzed by nonspecific plasma and tissue esterases. Allows profound analgesia without prolonged respiratory depression, but carries a risk of acute tolerance/hyperalgesia.
Dosage Guidelines
| Type | Route | Rate / Dose |
|---|---|---|
| Dosage/Guideline | Systemic | Load: 0.5-1 mcg/kg IV; Infusion: 0.1-1 mcg/kg/min. |
Black Box Warnings
- Rapid administration can induce severe chest wall rigidity.
Clinical Pearls
1
Ultra-short acting; rapidly hydrolyzed by nonspecific plasma and tissue esterases. Context-sensitive half-time is ~3 minutes regardless of infusion duration.