IV Sedatives & Hypnotics
FORNAS
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Calculated Induction Dose
--mg
Mechanism of Action
GABA-A agonist. Causes rapid unconsciousness with smooth awakening. Decreases CMR, CBF, and ICP. Can cause significant hypotension due to vasodilation.
Dosage Guidelines
| Type | Route | Rate / Dose |
|---|---|---|
| Dosage/Guideline | Systemic | Induction: 1.5–2.5 mg/kg IV; Infusion: 25–100 mcg/kg/min. |
Black Box Warnings
- Propofol Infusion Syndrome (PRIS): Prolonged infusions (>48h at >5 mg/kg/hr) can cause fatal bradycardia, rhabdomyolysis, metabolic acidosis, and multiorgan failure.
Clinical Pearls
1
Produces rapid awakening with minimal residual CNS effects. Decreases ICP, CBF, and CMR. Formulations support bacterial growth; strict sterile technique is required.