Naloxone

Reversal Agents

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Calculated Induction Dose
--mg

Mechanism of Action

Pure competitive opioid receptor antagonist (highest affinity for mu). Rapidly reverses opioid-induced respiratory depression and analgesia.

Dosage Guidelines

TypeRouteRate / Dose
Dosage/GuidelineSystemicBolus: 40–80 mcg IV (titrated for resp. depression); up to 1-4 mcg/kg.