Reversal Agents / Antidotes
Smart Dose Calculator
Calculated Induction Dose
--mg
Mechanism of Action
Glutathione analogue containing a sulfhydryl group that reduces and inactivates toxic metabolites.
Dosage Guidelines
| Type | Route | Rate / Dose |
|---|---|---|
| IV Protocol | IV | 150mg/kg over 60m, 50mg/kg over 4h, 100mg/kg over 16h. |
| Oral Protocol | PO | 140mg/kg load, then 70mg/kg q4h. |
Clinical Pearls
1
First-line antidote for treating acetaminophen overdose and hepatotoxicity.