Opioid Agonists
RESTRICTED
Smart Dose Calculator
Calculated Induction Dose
--mg
Mechanism of Action
Mu-opioid agonist. Slow onset due to low lipid solubility. Promotes histamine release. Active metabolites can accumulate in renal failure.
Dosage Guidelines
| Type | Route | Rate / Dose |
|---|---|---|
| Dosage/Guideline | Systemic | Bolus: 0.03–0.15 mg/kg IV; Intrathecal: 0.1-0.5 mg. |
Black Box Warnings
- Causes respiratory depression.
Clinical Pearls
1
Evokes histamine release, which can cause hypotension and bronchospasm.