Local Anesthetics
Smart Dose Calculator
Calculated Induction Dose
--mg
Mechanism of Action
Highly potent, long-acting amide LA. Carries a high risk of severe cardiotoxicity (refractory arrhythmias) if injected intravascularly due to slow dissociation from cardiac sodium channels.
Dosage Guidelines
| Type | Route | Rate / Dose |
|---|---|---|
| Dosage/Guideline | Systemic | Max dose: 3 mg/kg. |
Black Box Warnings
- Unintended intravascular injection can produce severe cardiovascular LAST, including refractory ventricular fibrillation and cardiac arrest.
Clinical Pearls
1
Highly potent, highly lipid-soluble with slow onset and long duration. Lipid emulsion (Intralipid 20%) is a first-line rescue treatment for cardiovascular toxicity.